Pregnenolone Supplements for Women: What You Need to Know

What You Need to Know About Taking Pregnenolone Supplements

The supplement market is saturated with many choices for women, and it can be difficult to determine which ones are right for your specific needs. When it comes to supplements like multivitamins, single vitamin tablets, capsules, or gummies, it’s crucial to do your homework. Determining whether a supplement may help you address a particular symptom or condition is essential before adding it to your daily supplementation regime.

Among the most beneficial supplements for women is pregnenolone. Learn more about pregnenolone and whether it could help you achieve your wellness goals.

Why Learn About Supplements?

There is a wide variety of supplements available in today’s market to improve women’s health. From multivitamins and women’s hormonal supplements to pre and post-natal supplements, these products have the potential to do everything from increasing your energy, honing your focus, and raising your libido to simply relaxing you. Some supplements are fine-tuned to the promise of positively influencing bone health, circulation, digestion, and inflammation, or addressing certain vitamin deficiencies or other ailments.

Choosing the right supplement for your body’s needs takes time, and it’s imperative to choose a provider fully vetted by an experienced team of pharmaceutical experts who are familiar with the causes behind each medical event or ongoing disorder. Even more importantly, a pharmacy only stocks supplements and vitamins created with safety, accessibility, and efficacy in mind. When you choose the right vitamins and supplements from a safe source, you can see positive and life-enhancing results.

What Is Pregnenolone?

Pregnenolone is a naturally occurring hormone that is created from cholesterol. Pregnenolone originates in the brain and adrenal glands but is also synthesized in organs such as the skin, liver, ovaries, and retina. The adrenal gland is responsible for producing pregnenolone, and it is one of the building blocks of progesterone, testosterone, cortisol, and other crucial hormones. The hormones it then builds classify pregnenolone as a “precursor hormone” for its crucial role in making steroidal hormones.

Pregnenolone is important not only in creating other hormones that regulate the body, but also the hormones that “cascade” directly from them. All these hormones work in tandem with one another to help balance the body’s response system. Hormones are especially important in balancing the responses of everyday stressors from environmental factors as well as mood and the immune system.

adrenal gland

Why Is Pregnenolone So Important?

Maintaining hormonal balance within the body is key to feeling healthy, and pregnenolone specifically works to regulate the balance between the hormones cortisol, DHEA, and progesterone. Together, these hormones function to enhance the body’s ability to cope with stress by producing the correct amounts of cortisol. This can be true even if you have a high-stress lifestyle due to work-life balance, environmental factors, or illness.

As early as the 1930s, pregnenolone was recognized for its important benefits to the brain. Although it is considered a steroid, it is essentially inactive in its isolated state, but it is critical because it acts as the precursor to other essential hormones. As a result, pregnenolone can influence brain functions in memory, learning, mood, and cognitive function. In addition, people with neuroinflammatory diseases typically show a lower level of pregnenolone, which indicates that this hormone can also benefit the body by reducing inflammation and protecting the immune system.

How Does Pregnenolone Affect Women?

How Does Pregnenolone Affect Women

Women who choose to take pregnenolone supplements often seek to alleviate excessive fatigue and boost their energy; others may use it to improve memory function, particularly as a result of the onset of Alzheimer’s disease. Still, others find that pregnenolone can help to address symptoms of trauma, promote healing from injuries, and aid in coping with stress and immune problems. Topically, pregnenolone has also been used to treat skin disorders, including psoriasis and scleroderma.

Because of the synthetic version’s positive effect on the regeneration of vital hormones, women also use pregnenolone to address fibrocystic breast disease, which causes breast tissue to form lumps. Other uses include the treatment of endometriosis, which causes excess uterine tissue to grow outside the uterus. Another common use is to alleviate symptoms of menopause, such as hot flashes, weight gain, fatigue, night sweats, sleep problems, and vaginal dryness, as well as premenstrual syndrome (PMS), which can cause painful uterine cramping, mood swings and irritability, depression, bloating, and difficulty sleeping.

Other uses of pregnenolone supplements are to help with the swelling and inflammation associated with arthritis. Pregnenolone may also enable the skin to maintain its elasticity, slowing or reversing wrinkles and lines. This supplement may alleviate feelings of depression and hopelessness, strengthen the heart’s ability to circulate blood throughout the body, and improve the ability to withstand different levels of exercise. Additionally, some try pregnenolone because it can help reduce symptoms of autoimmune disorders like multiple sclerosis (MS), lupus, or other hereditary afflictions like seizures.

Benefits of Pregnenolone for Women

Naturally occurring pregnenolone is a staple of the human body because it is the basis for the material that makes a number of essential hormones in women, who tend to experience greater hormonal fluctuations at certain periods of their lives or as a result of immunocompromisation. Women who suffer from depression, stress and anxiety, and other mood disorders may find relief from taking this in supplement form. In addition, pregnenolone may help improve sleep quality and duration, which can also have an even more beneficial impact on mood regulation and mental well-being.

Benefits of Pregnenolone for Women

Women who are trying to lose weight may also notice benefits from pregnenolone because it can increase energy and improve sleep quality, which in turn helps motivate people to move their bodies and exercise more often. It may also inhibit the production of cortisol–which may, in fact, be stress-induced–and begin to reduce bloating and fat deposits in the midsection.

If memory loss, lack of focus, or learning difficulties are posing problems, women may take this as a supplement to boost their brain power. Because pregnenolone helps the brain regenerate myelin, the brain then benefits from the increased protection surrounding its neurons. These can more quickly reform new synapses, potentially improving many aspects of memory, learning, and cognition.

Pregnenolone FAQs

While pregnenolone can have many benefits for women, it is essential to consider your condition, how pregnenolone works in the body, and determine your proper dosing before you make a purchase. Here are some of the most commonly asked pregnenolone questions.

How Much Pregnenolone Should a Woman Take?
Dosage will depend on a variety of factors, such as your age, what symptoms or illness you seek to treat, and more. Oftentimes, pharmacists suggest starting with a smaller dosage initially, then using this excellent information to determine how much you should administer moving forward. Our pharmaceutical doctors have extensive experience creating compounds in particular dosages to fit the needs of a wide variety of patients, and our retailers can assist as well with any questions or concerns surrounding dosing.

The typical starting dosage for pregnenolone supplementation is 30 mg, but the right dosage for your body type, age, and health requirements can vary and may change throughout the course of your treatment depending on how your body responds. As women age, their hormone levels decrease; therefore, if they decide to take pregnenolone as a supplement, a higher dosage may be more beneficial. In clinical settings, dosing is often used as a treatment at 100 mg, and in some research, settings have been given up to 700 mg.

How Do I Know if I Need Pregnenolone?
There are some warning signs to be aware of that may indicate that you could benefit from taking pregnenolone as a supplement. One obvious indicator is age because the older a woman becomes, the more health problems may begin to present – and many of these issues are rooted in hormonal imbalance. If your body has begun to slow the production of certain hormones such as progesterone, testosterone, estrogen, or cortisol, or lab tests indicate your body is not metabolizing hormones at the same rate it once was, you may be ready to try pregnenolone.

As pregnenolone can help ease women into the aging process and subdue some of the sudden and uncomfortable symptoms they may experience with menopause and getting older, the appearance of these symptoms is a likely sign you should consider pregnenolone. If your hormone fluctuations have impacted your day-to-life and you feel as though you cannot pay attention anymore, concentrate when you need to, or remember tasks, names, actions, and conversations, lack of pregnenolone may be a factor in these symptoms.

Likewise, if you experience excessive fatigue, sleepiness, and lack of energy, which is preventing you from enjoying life and being productive at work or other daily endeavors, this may be another indication of hormonal imbalance due to decreased pregnenolone. Other physical symptoms that manifest in some women are excessively dry skin in the form of psoriasis or scleroderma, joint pain and inflammation, and muscle stiffness and sensitivity. Some women report that their sex drive has decreased or become non-existent; this is often due to hormone reduction in the body.

An adult woman aged 18 or older may present with anywhere from 33 ng/dL to 248 ng/dL (nanogram per deciliter) of pregnenolone in a blood test. If a laboratory test indicates that an adult woman has a low amount of pregnenolone, they may be a good candidate for a supplement.

What Are the Side Effects of Pregnenolone Supplements?
As with any medicine or supplement, there is a minimal risk of adverse effects. Some side effects may be so mild that they are canceled out by the benefits, but you should be aware of them nonetheless. After taking pregnenolone supplements for 1-3 months, some women experienced mood swings, anxiety attacks, increased fatigue, headaches, and irregular heart rhythm. These symptoms manifested themselves in isolation as well as in the presence of other medications, so if you choose to take pregnenolone supplements, monitor your reactions for anything that may cause concern.

If you have prescriptions for other medications, as well, consider asking a compounding pharmacist to compound medication for you. This can help you combine several medications into one and reduce the number of medications you need to take on a daily basis.

Why Purchase Pregnenolone from Compounding Pharmacy of America?
Depending on a patient’s unique needs and based on their age, health history, lifestyle, and physical and mental health goals, a compounding pharmacy can help you tailor treatment and dosage to have the most beneficial impact and help you move forward with positive, proactive, and effective results. Buying a supplement over-the-counter from a larger retailer may be convenient at the moment, but Compounding Pharmacy of America’s dedicated and experienced team of pharmaceutical doctors can help you pinpoint how pregnenolone can improve your experience.

Take Charge of Your Health at Any Age

Regardless of your age, you may be experiencing uncomfortable or debilitating symptoms that have impacted your quality of life, or you may have been diagnosed with a disorder that has altered your normal capabilities. If this is the case, consider the benefits of safe, high-quality supplemental pregnenolone. It may feel daunting or embarrassing to admit that your memory and concentration are faltering or that you are experiencing painful dryness in private areas or manifesting itself as an unsightly and uncomfortable skin condition, but you should not feel as though you must bear these symptoms alone.

Many women avoid discussing the discomforts of menopause or their lack of interest in sex with their partner with a physician. Others may simply associate joint and muscle pain with old age. However, you should know that you can benefit by kickstarting your hormone production with the reintroduction of the correct levels of pregnenolone in supplement form.

Pregnenolone 25 mg

Remember also that supplements are not a magic bullet – the more you make positive changes in your lifestyle, the better they will work. The good news is that starting on a pregnenolone dose can positively impact your energy levels, focus, concentration, mood, weight, and more. This can, in turn, function as positive motivation to embark on a more holistic wellness journey that will benefit you in the long run, not just as a temporary fix. The important thing to remember when considering pregnenolone is that hormone imbalance, fluctuation, and the increase or decrease of levels throughout a woman’s life are completely natural and normal, and you do not need to accept pain, discomfort, mental anguish or a limited quality of life because of it.

Positive changes in your lifestyle

Don’t hesitate to find out how pregnenolone can help you to reclaim your life, your vitality, and your purpose. At Compounding Pharmacy of America, we are reading to help you in pursuing the healthy lifestyle you want and deserve. Pregnenolone may be a key element in creating this new you.


Resources :

  1. What Should Women Know About Vitamins and Supplements? (2022, July 14). University of Utah Health | University of Utah Health.https://healthcare.utah.edu/the-scope/health-library/all/2022/07/what-should-women-know-about-vitamins-and-supplements
  2. Murugan, S., Jakka, P., Namani, S., Mujumdar, V., & Radhakrishnan, G. (2019). The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation. Journal of Biological Chemistry, 294(12), 4596–4607. https://doi.org/10.1074/jbc.ra118.005543
  3. Pregnenolone: Health Benefits, Side Effects, Uses, Dose & Precautions. (n.d.). RxList. Retrieved September 5, 2023, from https://www.rxlist.com/pregnenolone/supplements.htm
  4. Perishable. (2015, September 2). Pregnenolone: What You Need to Know | USADA. https://www.usada.org/spirit-of-sport/education/pregnenolone/
  5. Frank, D. (2021, April 27). What Are The Symptoms Of Low Pregnenolone? Walkin Lab. https://www.walkinlab.com/blog/symptoms-low-pregnenolone/#:~:text=Warning%20signs%20of%20low%20pregnenolone&text=If%20pregnenolone%20production%20declines%2C%20the,by%20insufficient%20attention%20and%20concentration

About Matt Poteet, Pharm.D.

Chief Operating Officer, The Compounding Pharmacy of America Matthew Poteet, Pharm.D. graduated with Honors from Lee University with a Bachelors of Science in Biological Science. After his undergraduate training, he completed the Doctor of Pharmacy program at Mercer University Southern School of Pharmacy, graduating in 2004. Dr. Poteet has spent much of his pharmacy career on staff at two of the most prestigious academic teaching hospitals in the Southeast; Emory University in Atlanta and Vanderbilt University Medical Center in Nashville. At these institutions he received extensive experience and training in sterile products compounding. He returned home to East Tennessee in 2010, where he has held the position of Pharmacy Director at two sterile products pharmacies in Knoxville. Matthew lives in Knoxville with his wife, Chris. Dr. Poteet is Tennessee’s first Board Certified Anti-Aging Pharmacist by the American Academy of Anti-Aging Medicine. Read More About Matthew Poteet, PharmD